On a weekly basis any hiring manager probably receives between 50 to well probably hundreds of resumes and cover letters. The key is to catch their attention from the start and the best place to do that is in your cover letter. So I am going to tell you what the worst possible way is to start your cover letter and then give you some creative alternatives to use instead.

This is the most boring intro line because everyone uses it:

Please accept my resume for consideration of the (XYZ) position within your organization.

What a snoozer! Everyone uses that line, let's see... being like everyone else isn't going to get you very far in your job search now is it? No it's not. So what you need to be is different but more than different unique and valuable. Let's take a look at some more creative and attention grabbing opening lines:

Administrative:
If you are spending too much time on tedious office duties and administrative tasks then I have the solution for you. My experiences in office administration and client services have equipped me with a multitude of skills including office management, business operations and exemplary customer service. I am confident that my application of these and my many other skills would be an asset to your company.

Customer Service:
It's twice as hard to attract a new customer as it is to maintain an existing one. Unfortunately, this fact is often overlooked by many businesses. Delivering high-quality, responsive service is vital in (industry ex. Banking) and that's exactly what you'll get when you hire me. As my resume indicates, I have worked in client services for more than (number) years so you won't have to go to great expense training me.

Non-profit:
In today's challenging economic climate, many people will respond to your advertisement. Few will be interviewed. One will be hired.

However ...

Of the many to respond, few will be as qualified as I am, having in-depth experience in community and public outreach. No one else will bring my track record and the expertise I can offer - expertise that equips me to start delivering results for you immediately with maximum positive effect for your bottom line.

General:
Integrity. Innovation. Initiative. If you had these qualities in mind for the position of (position title) then I suggest we meet to discuss the numerous qualifications I would bring to the organization. With my demonstrated track record of successfully directing pharmacy operations and introducing initiatives that directly impact the bottom line, I am confident that I would be an excellent fit for the position at (company name).

Of course these are only a few sample introductions and the remainder of your cover letter needs to be just as dynamic as the introduction, but nothing is more important then that initial first impression and you are sure to when them over when you choose something unique, creative, and captivating.